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Once permanent residence (properly known as indefinite leave to remain) has been granted, there are no longer any immigration related restrictions on the work or business you may do in the UK, and no time limits on your stay in the UK.
You should note that to keep your permanent residence you should not spend longer than two years outside the UK. You should maintain ties to the UK and should consider the UK as your home. If you continue to only spend short periods of time in the UK over many years it is likely that there will come a time when you will lose your indefinite leave to remain in the UK. It is therefore beneficial in most cases to apply for UK citizenship. You can normally apply for naturalisation as an UK citizen one year after being granted indefinite leave to remain and as long as you meet the residence requirements.